Some oral contraceptives may be linked to gallbladder disease risk.MedPage Today (4/20, Baron-Faust) reported that "some of the newest and most popular oral contraceptives -- including the drospirenone/ethinyl estradiol combo marketed as Yaz -- have been linked to a small, but significant risk of gallbladder disease, according to a large retrospective cohortstudy " published in the CMAJ. The researchers, who looked at data on "nearly three million women taking ethinyl estradiol combined with one of seven progestins between 1997 and 2009, found a small, but statistically significant risk of having gallstones for drospirenone (adjusted RR 1.20, 95% CI 1.16 to 1.26)." The investigators "also found a similar risk of gallbladder disease...for desogestrel (adjusted RR 1.05, 95% CI 1.01 to 1.09) and for norethindrone (adjusted RR 1.10, 95% CI 1.06 to 1.14) compared with the older progestin levonorgestrel RR 1.00 (ref)."
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